Don’t Let Resource Limitations Stop You from Implementing Personalized Dosimetry in Theranostics

Overcome barriers to adopting dosimetry in radiopharmaceutical therapies (RPT) and move beyond one-size-fits-all treatments.

Personalized Dosimetry Is Essential for RPT

The upward trajectory of PSMA-targeted RPTs seems unstoppable. The soon-to-be-completed Phase III trials PSMAfore, PSMAddition, SPLASH, and ECLIPSE investigate the use of these drugs in earlier-stage metastatic prostate cancers, potentially opening access to a vast population of patients.

Meanwhile, evidence is mounting that personalized radiation dosimetry is just as essential for RPT—also known as Molecular Radiotherapy (MRT)—as it is for external-beam radiotherapy (EBRT) and ⁹⁰Y microsphere therapies.

But, implementing a dosimetry regimen is often associated with increased resource requirements, and clinics are already stretched thin. If resource limitations are stopping you from implementing dosimetry, consider the points below.

Tailor Dosimetry to Existing Resources

Dosimetry can be tailored to the resources that are already available at your clinic. That’s what Jonathan Gear et al. demonstrate in their recent EANM Enabling Guide: How to Improve the Accessibility of Clinical Dosimetry.

The authors provide a roadmap for clinics that want to implement dosimetry but lack the resources of more established centers. Because RPT is often a multidisciplinary effort, the article walks through different possible staffing strategies depending on:

• Whether your team has access to a medical physicist
• The availability of the treating Nuclear Medicine (NM) physician to be involved in practical aspects like contouring
• The familiarity of NM technologists with the dosimetry protocol

Possibilities for getting the most out of existing imaging equipment are also covered, such as using stand-alone SPECT and CT acquisitions, and relying on reduced-time-point or single-time-point imaging techniques.

To help you get a concrete sense of the wide variety of possible approaches to implementing dosimetry, a supplemental guide is included with the article. The guide outlines two possible dosimetry strategies with advantages and disadvantages for ¹³¹I-Sodium Iodide, ¹⁷⁷Lu-DOTATATE, and ¹³¹I-MIBG.

Extend Resources with Automation

Organ segmentation and dosimetry calculations are examples of tasks that commonly require significant manual intervention. Automated software tools like MIM SurePlan™ MRT ease the manual burden and play an essential role in enabling dosimetry for RPT when staff resources are limited.

MIM SurePlan MRT lets you start the dosimetry process without having to do anything manually: quantitative SPECT reconstruction and AI-driven organ segmentation can be triggered to run with no manual input. Leveraging specialized algorithms, the dosimetry process itself is also automated, flexible, and robust. All relevant information is packaged in a streamlined interface for physician review.

In short, automation can be the difference between personalized dosimetry and one-size-fits-all RPT.

See why MIM SurePlan MRT has quickly become the standard application used for RPT in Centers of Excellence across North America.